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Beaumont Laboratory

Vitamin E Level

Alpha-tocopherol Levels, Vitamin E, Serum, MAYO: VITE, EPIC: LAB6182, SOFT: XVITE


  • The patient must be fasting 12-14 hours prior to specimen collection (for infants, collect specimen just prior to next schedule feeding).


Specimen Collection Criteria

Collect: One plain Red-top tube.
Also acceptable: One Gold-top SST tube.

Physician Office/Drawsite Specimen Preparation

Protect specimen from light. Let specimen clot 30-60 minutes and immediately centrifuge to separate serum from cells. Transfer serum to an amber plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 0.5 mL light-protected serum, refrigerated (2-8°C or 36-46°F). (Min: 0.25 mL)

Rejection Criteria

  • Hemolyzed specimens.
  • Lipemic specimens.
  • Specimens not collected and processed as indicated.
  • Specimens not protected from light.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to Mayo Medical Laboratories, Rochester, MN.


Monday - Friday.
Results available in 3-6 days.

Reference Range

By report.

Test Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Specific quantitation of alpha-tocopherol.


Serum vitamin E concentrations are correlated with serum lipids, and accurate assessment may require calculation of a lipid ratio.

Significant deficiency of vitamin E (less than 3.0 mg/L) is associated with improper specimen collection and malabsorption syndromes. Significant excess (greater than 40 mg/L) is often associated with hyperlipidemia.

Clinical Utility

This assay is used to evaluate vitamin E deficiency in hemolytic disease in premature infants, and neuromuscular disease in infants (and adults) with chronic cholestasis. It is also used to evaluate patients on long-term parenteral nutrition, patients with malignancy or malabsorption, and to investigate brown-bowel syndrome. Infertility in both males and females may be a manifestation of vitamin E deficiency. Vitamin E has been used for the treatment of habitual abortion and sterility. There has been no conclusive evidence that vitamin E has any beneficial effect on these conditions. High doses of vitamin E appear to be tolerated without significant adverse effects.

CPT Code


Test Codes


Last Updated


Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.