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Beaumont Laboratory


ARUP: 91568, Order as a Miscellaneous Sendout.

Specimen Collection Criteria

Collect (preferred specimen): One Lavender-top EDTA tube (Minimum Whole Blood: 0.3 mL).

Physician Office/Drawsite Specimen Preparation

Do not centrifuge. Maintain specimen at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: Whole blood specimen, refrigerated (2-8°C or 36-46°F). (Min: 0.3 mL)

Rejection Criteria

  • Frozen specimens.
  • Specimens not collected and processed as indicated. 


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 3 months
Refrigerated (2-8°C or 36-46°F): 3 months
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT, forwarded to National Medical Services (NMS), Willow Grove, PA.


Results available in 4-11 days.

Reference Range

By report.

Test Methodology

Quantitative Spectrophotometry.


Sulfhemoglobin is a moiety of normal hemoglobin with a sulfur atom incorporated into the porphyrin ring. Because of this change the hemoglobin is unable to bind oxygen.

Sulfhemoglobinemia may be induced by drugs (e.g., flutamide, acetanilide, diapason), exposure to sulfur dioxide, hydrogen sulfide, trinitrotoluene and severe air pollution.

Sulfhemoglobin often accompanies drug induced methemoglobinemia and is also associated with cyanosis. In contrast to methemoglobinemia that responds to treatment with methylene blue or ascorbic acid, sulfhemoglobin persists until the erythrocytes containing it are destroyed. The blood level of sulfhemoglobin declines gradually over a period of weeks.

Patients with sulfhemoglobinemia often also have methemoglobinemia. Therapy is directed at reversing the methemoglobinemia present.

Clinical Utility

This assay aids in the diagnosis of sulfhemoglobinemia.

CPT Code


Test Codes

ARUP: 91568, Order as a Miscellaneous Sendout.

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.