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Beaumont Laboratory

Streptomycin Serum Level, HPLC


Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Green-top Sodium Heparin tube.

Do not use Serum Separator Tubes.

Physician Office/Drawsite Specimen Preparation

Centrifuge to separate serum or plasma from cells. Transfer serum or plasma to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Preparation for Courier Transport

Transport: 2.0 mL serum, frozen (-20°C/-4°F or below). (Min: 0.5 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Grossly hemolyzed specimens.
  • Specimen not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 24 hours
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to Focus Technologies, San Juan Capistrano, CA, forwarded to National Jewish Health, Denver, CO.


Monday - Friday.
Results available within 3-8 days.

Reference Range

By report.

Test Methodology

High Performance Liquid Chromatography (HPLC).


Specimens collected within 15 minutes of the next antibiotic dose represent the trough levels. Specimens obtained within 15-30 minutes after the end of I.V. infusion or 45-60 minutes after an IM injection represent the peak levels.

Sulindac may interfere with this assay.

Clinical Utility

Streptomycin is a systemic aminoglycoside. It is used primarily as an antitubercular and is active against Mycobacterium tuberculosis and M. bovis. It is also considered the drug of choice for the treatment of infections caused by Francisella tularensis and Yersinia pestis, and is often used to treat Brucella infections. Because many other gram-negative bacilli are resistant, streptomycin is rarely used to treat those organisms.

CPT Code


Test Codes


Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.