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Beaumont Laboratory

Vanillylmandelic Acid (VMA), Urine Random

VMA, Urine Vanillylmandelic Acid, Vanillymandelic Acid (VMA), Vanillylmandelic Acid, Urine (VMA), ARUP #80421, Random Urine, EPIC: LAB7067, SOFT: XVMA

Specimen Collection Criteria

Collect: Random urine specimen in a screw-capped container (preferred) or other sterile collection cup. (Minimum Volume: 3.0 mL)

Note: This test is only offered on patients 16 years of age or younger, 24 hour collection is the preferred sample.

Physician Office/Drawsite Specimen Preparation

Maintain specimens refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: Random urine, refrigerated (2-8°C or 36-46°F).

Rejection Criteria

  • Samples not kept refrigerated (2-8°C or 36-46°F).
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT.


Tuesday - Sunday.
Results available 2-6 weeks.

Reference Range

By report.

Test Methodology

Quantitative High-Performance Liquid Chromatography (HPLC)/Tandem Mass.


Elevated levels are seen in cases of pheochromocytoma, neuroblastoma, ganglioneuroma and in some cases of carcinoid tumor.

Clinical Utility

Vanillylmandelic Acid is the primary metabolite of the catecholamines. Quantitation of VMA has been valuable in the diagnosis and follow-up of patients with phenochromocytoma and related neurogenic tumors. Catecholamine-secreting tumors are surgically curable; therefore, it may be desirable to evaluate hypertensive patients for this possible cause.

CPT Code


Test Codes

ARUP #80421, Random Urine, EPIC: LAB7067, SOFT: XVMA

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.