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Beaumont Laboratory

Manganese, Serum



Diet, medication, and nutritional supplements may introduce interfering substances. Patient should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).

Specimen Collection Criteria

Collect: One Royal Blue-top tube with no additives.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within six hours of collection. Transfer serum to a metal free transport tube. Maintain specimen at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 2.0 mL serum, at room temperature (20-26°C or 68-78.8°F). (Min: 0.5 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Hemolyzed specimens.
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Indefinite
Refrigerated (2-8°C or 36-46°F): Indefinite
Frozen (-20°C/-4°F or below): Indefinite

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT.


Sunday, Wednesday.
Results available in 2-6 days.

Reference Range

0.0-2.0 mcg/L.

Test Methodology

Quantitative Inductively Coupled Plasma/Mass Spectrometry.


  • Increased manganese levels are seen in acute hepatitis and myocardial infarction.
  • Decreased levels are seen in seizure disorders, maple syrup urine disease, phenylketonuria, and in certain patients with bone and joint malformations. A true deficiency state (due to decreased intake) has not been described for manganese.
  • Toxicity results primarily from inhalation of particulate material containing high levels of manganese. Manganese toxicity occurs in miners, foundry workers, welders, pharmaceutical workers, pottery and ceramics makers, varnish manufacturers, and in makers of food additives.
  • Elevated results from noncertified trace element-free collection tubes may be due to contamination. Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as a Royal Blue-top sterile tube (no additive).

Clinical Utility

This assay is used to detect toxic manganese exposure, especially neurological syndromes and movement disorders. It is also used to follow manganese therapy in parenteral nutrition especially in patients with liver disease or that have excessive gastrointestinal losses.

CPT Code


Test Codes


Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.