Beaumont Laboratory - Lab Test Details
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Beaumont Laboratory

Immunoglobulin M (IgM)

IgM , Immunoglobulin M, Serum, Antrim #30470, EPIC: LAB5788, SOFT: IGM

Specimen Collection Criteria

Collect: One Gold-top SST tube. (Minimum Whole Blood: 4.0 mL)

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within 12 hours of collection. (Minimum Serum: 0.5 mL)

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL)

Rejection Criteria

  • Grossly lipemic specimens.
  • Hemolyzed specimens.
  • Plasma specimens.

Storage

Specimen Stability for Testing:

Centrifuged SST tubes, Red-top tubes, and Microtainers®
Room Temperature (20-26°C or 68-78.8°F): 12 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 12 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Automated Chemistry Laboratory.

Performed

Sunday - Saturday.
Results available within 24 hours of receipt in the Laboratory.

Reference Range

0-29 Days: 12-28 mg/dL
1-3 Months: 27-113 mg/dL
4-6 Months: 30-86 mg/dL
7-12 Months: 33-74 mg/dL
13-24 Months: 33-159 mg/dL
25-36 Months: 45-133 mg/dL
3-5 Years: 45-166 mg/dL
6-8 Years: 53-161 mg/dL
9-11 Years: 49-239 mg/dL
12-16 Years: 48-253 mg/dL
Adult Range: 47-206 mg/dL

Test Methodology

Nephelometry.

Interpretation

Decreased IgM levels are associated with selective hypo-IgM and protein-losing enteropathies.

Increased IgM levels are associated with acute viral infections, recent immunization, parasitic disorders (e.g., trypanosomiasis, malaria, toxoplasmosis), Waldenstrom's macroglobulinemia, IgM myeloma, Hyper-IgM syndrome, and hepatitis.

Half Life in Blood: 5 days.

Clinical Utility

IgM levels can be used to evaluate humoral immunity and to assist in the diagnosis of conditions associated with IgM excess or depression. IgM is the first antibody to appear in a primary antibody response. IgM does not cross the placenta. Increased IgM levels in the newborn are associated with intrauterine infections.

CPT Code

82784.

Test Codes

Antrim #30470, EPIC: LAB5788, SOFT: IGM

Last Updated

03/17/2016

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.