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Beaumont Laboratory

Hypoglycemic Agent Screen

Sulfonylureas (chlorpropamide, tolazamide, tolbutamide, acetohexamide, glipizide, glyburide, glimepiride), Meglitinides (repaglinide), MAYO: HYPOG, EPIC: LAB6279, SOFT: XHYPG

Specimen Collection Criteria

Collect: One plain Red-top tube.

Do not use Serum Separator Tubes.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes and centrifuge to separate serum from cells. Transport serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 3.0 mL serum, frozen (-20°C/-4°F or below). (Min: 1.1 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Grossly icteric specimens.
  • Grossly lipemic specimens.
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 14 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to Mayo Medical Laboratories, Rochester, MN.


Monday, Wednesday, Friday.
Results available in 3-9 days.

Reference Range

By report.

Test Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

Clinical Utility

The metabolic and hormonal profiles of insulinoma and sulfonylurea-induced hypoglycemia are identical. Therefore, in the evaluation of the hypoglycemic patient, the possible use of oral hypoglycemic agents as the cause for low blood glucose and elevated plasma insulin must be considered. Absence of hypoglycemic drugs in blood serum during an episode of low blood glucose should be demonstrated before considering pancreatic exploration for suspected insulinoma.

CPT Code


Test Codes


Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.