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Beaumont Laboratory

Human Anti Mouse Antibody

HAMA, Human Anti-Mouse Antibody, ARUP #98299, EPIC: LAB6277, SOFT: XHAMA

Specimen Collection Criteria

Collect: One plain Red-top tube.

Do not use Serum Separator Tubes.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 1.0 mL serum, frozen (-20°C/-4°F or below). (Min: 0.5 mL)

Rejection Criteria

  • Grossly lipemic specimens.
  • Serum Separator (SST) tubes.
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 24 hours
Frozen (-20°C/-4°F or below): 21 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT, forwarded to Quest Diagnostics, San Juan Capistrano, CA.


Results available in 8-18 days.

Reference Range

By report.

Test Methodology

Quantitative Enzyme-Linked Immunosorbent Assay.

Clinical Utility

In patients receiving multiple injections of murine monoclonal IgG, immune response directed against the same IgG, may produce significant level of Human Anti-Mouse Antibodies (HAMA) in serum. Circulating levels of HAMA can bind to the injected IgG and reduce the efficacy of the antibody therapy. Also, approxmately 9% of a normal population have pre-existing HAMA reactivity without the administration of murine monoclonal IgG.

Human anti-animal antibodies cause interferences in immunological assays. The most common human anti-animal antibody interferent is HAMA. This can cause both positive and negative interferences in two-site antibody-based assays.

CPT Code


Test Codes


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.