Liver/Kidney Microsome Type 1 Antibody, IgG
P450 2D6 Antibody, WARDE: LKMAB, EPIC: LAB6086, SOFT: XLKM
Specimen Collection Criteria
Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.
Physician Office/Drawsite Specimen Preparation
Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).
Preparation for Courier Transport
Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Min: 0.2 mL)
- Lipemic specimens.
- Severely hemolyzed specimens.
- Specimens not collected and processed as indicated.
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 21 days
Frozen (-20°C/-4°F or below): 30 days
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.
Sent to Warde Medical Laboratory, Ann Arbor, MI.
Results available in 2-5 days.
Negative: Less than or equal to 20.0 Units.
Equivocal: 20.1-24.9 Units.
Positive: Greater than or equal to 25.0 Units.
Enzyme Immunoassay (EIA).
LKM (liver kidney microsome) autoantibodies are found in a subgroup of patients with ANA-negative autoimmune chronic active hepatitis. Antibody to hepatitis C virus can be found in about 50% of patients with low LKM autoantibody titers.
Antibodies to liver kidney microsome antigens (anti-LKM1) occur in a subset of patients with chronic autoimmune hepatitis. These patients have a high frequency of associated immunologic disorders and an absence of non-organ specific autoantibodies (smooth muscle antibodies). Most patients with with type of chronic autoimmune hepatitis are children.
This assay is used to detect a clinically specific antibody in patients with autoimmune chronic hepatitis (type 2).
WARDE: LKMAB, EPIC: LAB6086, SOFT: XLKM
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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills,
Grosse Pointe, Royal Oak, and Troy campuses.