Helicobacter Pylori Antigen, Stool
Campylobacter pylori, H. pylori, gastritis, Helicobacter pylori Antigen, Stool , EPIC: LAB7094, SOFT: XHPAG
Patients should not take antibiotics, bismuth preparations, or proton pump inhibitors for two weeks prior to testing.
Specimen Collection Criteria
Collect: Random stool specimen (10 grams) in a sterile collection container with no preservatives. (Min: 1.0 g)
Physician Office/Drawsite Specimen Preparation
Maintain specimen frozen (-20°C/-4°F or below) prior to transport.
Preparation for Courier Transport
Transport: Stool in a sterile collection container, frozen (-20°C/-4°F or below). (Min: 1.0 g)
- Rectal swabs.
- Watery stools.
- Stool specimens received in transport media or preservative.
- 24 hour collection of stool.
Refrigerated (2-8oC): 72 hours
Frozen (-70oC): for longer storage. (Specimens may be frozen
and thawed twice.)
Saturday - Sunday.
Results available 4-6 days.
Negative for H. pylori antigen.
Enzyme Immunoassay (EIA).
The sensitivity of the assay has been reported to be 89% with a 94-95% specificity.
Antimicrobials, proton pump inhibitors and bismuth preparations are known to suppress H. pylori growth. Ingestion of these agents within two weeks of H. pylori antigen may produce false negative results.
Testing to confirm eradication of H. pylori should be done four or more weeks after completion of therapy.
This assay provides a non-invasive method for the identification of Helicobacter pylori in stool. Test results are intended to aid in the diagnosis of H. pylori infection, and to monitor response during and after therapy in adult patients.
Nearly 70% of gastric ulcers and more than 90% of duodenal ulcers have been associated with H. pylori infections. H. pylori infection has also been associated with adenocarcinoma of the stomach. Nearly all patients with H. pylori have antral gastritis.
- Lawson, A.J. 2011. Heliobacter. Manual of Clinical Microbiology, 10th edition. Versalovic, J. et. al. (eds.) ASM Press. Washington, D.C.
EPIC: LAB7094, SOFT: XHPAG