Hepatitis E Ab, IgG

Hepatitis E IgG, Hepatitis E Antibody, IgG , ARUP #2010151, EPIC: LAB6621, SOFT: XHPEG

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube or one Lavender-top EDTA tube.

Send specimen for processing immediately after collection. 

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Min: 0.3 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.


Ambient: 2 weeks
Refrigerated: 2 months


Tuesday, Friday.
Results available in 2-9 days.

Reference Range

By report.

Test Methodology

Qualitative Enzyme-Linked Immunosorbent Assay (ELISA).


Both IgM and IgG antibody to HEV (anti-HEV) are elicited following HEV infection. The titer of IgM anti-HEV declines rapidly during early convalescence. IgG anti-HEV persists and appears to provide at least short-term protection against disease.

Clinical Utility

This test is used for the in vitro detection of IgG and IgM antibodies to hepatitis E virus in human serum.

Clinical Disease

The epidemiology and clinical course of viral hepatitis E are similar to that of hepatitis A. There is no evidence of a chronic form. The case fatality rate is similar to that of hepatitis A, except in pregnant women where the rate may reach 20% during the third trimester of pregnancy.


  1. Benenson, Abram. Control of Communicable Diseases in Man, 15th edition, American Public Health Association, Washington, DC. 1990.

CPT Code


Test Codes

ARUP #2010151, EPIC: LAB6621, SOFT: XHPEG

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