Hypersensitivity Pneumonitis II

ARUP #55226, EPIC: LAB6067, SOFT: XHYP2


This panel includes:

  • Aspergillus flavus Antibody
  • Aspergillus fumigatus #2 Antibody
  • Asperigillus fumigatus #3 Antibody
  • Saccharomonospora viridis Antibody
  • Thermoactinomyces candidus Antibody
  • Thermoactinomyces sacchari Antibody

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Min: 0.15 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.


After separation from clot:
Ambient: 2 days
Refrigerated: 14 days
Frozen: 1 year (avoid repeated freeze/thaw cycles)


Monday - Friday.
Results available in 4-6 days.

Reference Range

Aspergillus flavus Antibody: None detected.
Aspergillus fumigatus #2 Antibody: None detected.
Asperigillus fumigatus #3 Antibody: None detected.
Saccharomonospora viridis Antibody: None detected.
Thermoactinomyces candidus Antibody: None detected.
Thermoactinomyces sacchari Antibody: None detected.

Test Methodology

Qualitative Immunodiffusion.


Precipitating antibodies against the offending antigen can be demonstrated in most active cases of hypersensitivity pneumonitis. However, a positive test does not always indicate active disease since asymptomatic individuals may develop precipitins without any features of hypersensitivity. A positive test is a helpful diagnostic tool when supported by historical and clinical evidence. The absence of a positive test does not rule out hypersensitivity pneumonitis.

Analyte Specific Reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration approval. This test was developed and its performance characteristics determined by ARUP Laboratories, Inc. It has not been approved by the U.S. Food and Drug Administration. This test should not be regarded as investigational or for research use.

Clinical Utility

This assay aids in the diagnosis of hypersensitivity pneumonitis.

CPT Code

86331x3, 86606x3.

Test Codes

ARUP #55226, EPIC: LAB6067, SOFT: XHYP2

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