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Inflammatory Bowel Disease Serology (Southeast Michigan Only)

IBD Panel: S cerevisiae Antibody IgG and IgA, ANCA IFA

Test Codes

EPIC: LAB1231556, Beaker: XIBDS, ARUP: 3003748

Department

Send Outs

Specimen Collection Criteria

Collect: One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within 2 hours. Transfer 1.5 mL serum to plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.6 mL)

Rejection Criteria

• Contaminated specimen.
• Heat-inactivated specimen
• Grossly hemolyzed specimens.
• Grossly lipemic specimens.
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within 2 hours. Transfer serum to plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.6 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 48 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories in Salt Lake City, UT.

Performed

Saturday – Sunday
Results available in 1-4 days.

Reference Range

By report.

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)/Indirect Fluorescent Assay (IFA).

Interpretation

The term "inflammatory bowel disease" (IBD) is often used to refer to 2 diseases, ulcerative colitis (UC), and Crohn's disease (CD), that produce inflammation of the large or small intestines.

Patients with IBD have been shown to have antibodies in serum that help to distinguish between UC and CD. Patients with UC often have measurable neutrophil atypical perinuclear anti cystoplasmic antibodies (Atypical P-ANCA), which react with as yet uncharacterized target antigens in human neutrophils; whereas patients with CD often have measurable antibodies, which react with the Saccharomyces cerevisiae strain Su 1.

Clinical Utility

As an adjunct in the diagnosis of UC and CD in patients suspected of having IBD.

CPT Codes

86671 x2, 86255, if reflexed add 86256.

Contacts

Last Updated

11/1/2024