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Quetiapine

Seroquel

Test Codes

EPIC: LAB6326, Beaker: XQUET, Mayo: FQUET

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One dark green-top sodium heparin tube.

Do not use Serum Separator Tubes.

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 3.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.6 mL)

Rejection Criteria

• Serum Separator (SST) tubes.
• Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 3.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.6 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 180 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN. Forwarded to Medtox Laboratories.

Performed

Sunday – Monday
Results available within 6-10 days.

Reference Range

By report.

Test Methodology

Quantitative Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS).

Interpretation

Quetiapine (Seroquel®) is rapidly absorbed following oral administration, with peak plasma concentrations obtained in 1 to 1.5 hours post dose.

Clinical Utility

This assay aids in the therapeutic drug monitoring of Quetiapine. Quetiapine (Seroquel®) is a new, FDA-approved agent for management of the manifestations of psychotic disorders, including schizophrenia. A structural analogue of Clozapine, Quetiapine addresses the signs and symptoms of schizophrenia, but has fewer side effects.

Reference

1. Gunasekara, N.S. and Spencer, C.M., Quetiapine- A Review of its Use in Schizophrenia, CNS Drugs, 9(4): 325-340, 1998.

CPT Codes

80342

Contacts

Last Updated

11/6/2023