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Manganese, Whole Blood

Test Codes

EPIC: LAB1231455, Beaker: XMNGB, Mayo: MNB

Department

Send Outs

Instructions

High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Specimen Collection Criteria

Collect: One Royal Blue-top EDTA tube. (Minimum: 1.0 mL)

Physician Office/Draw Specimen Preparation

Do not centrifuge. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 1.0 mL whole blood, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.2 mL)

Rejection Criteria

Specimens not collected or processed as indicated.

In-Lab Processing

Do not centrifuge. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport.

Transport: 1.0 mL whole blood, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.2 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 28 days
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Monday.
Results available in 2-8 days.

Reference Range

By report.

Test Methodology

Triple-Quadruple Inductively Coupled Plasma-Mass Spectrometry (ICP-MS/MS).

Interpretation

• Increased manganese levels are seen in acute hepatitis and myocardial infarction.
• Decreased levels are seen in seizure disorders, maple syrup urine disease, phenylketonuria, and in certain patients with bone and joint malformations. A true deficiency state (due to decreased intake) has not been described for manganese.
• Toxicity results primarily from inhalation of particulate material containing high levels of manganese. Manganese toxicity occurs in miners, foundry workers, welders, pharmaceutical workers, pottery and ceramics makers, varnish manufacturers, and in makers of food additives.
• Elevated results from noncertified trace element-free collection tubes may be due to contamination. Elevated concentrations of trace elements in blood should be confirmed with a second specimen collected in a tube designed for trace element determinations, such as a royal blue, Na₂EDTA tube.

Clinical Utility

This assay is used to detect toxic manganese exposure, especially neurological syndromes and movement disorders. It is also used to follow manganese therapy in parental nutrition especially in patients with liver disease or that have excessive gastrointestinal losses.

CPT Codes

83785

Contacts

Last Updated

7/21/2024