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Manganese, Serum

Test Codes

EPIC: LAB6092, Beaker: XMANG, Mayo: MNS

Department

Send Outs

Instructions

High concentrations of gadolinium, iodine, and barium are known to interfere with most metal tests. If gadolinium-, iodine, or barium-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Specimen Collection Criteria

Collect: One Royal Blue-top tube with no additives.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within six hours of collection. Transfer serum to a metal free transport tube. Maintain specimen at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 1.6 mL serum, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.4 mL)

Rejection Criteria

• Serum Separator (SST) tubes or tubes that are not metal-free.
• Hemolyzed specimens.
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a metal free transport tube within six hours of collection. Maintain specimen at room temperature (20-26°C or 68-78.8°F) prior to transport.

Transport: 1.6 mL serum, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.4 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 28 days
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Thursday.
Results available in 2-7 days.

Reference Range

By report.

Test Methodology

Triple-Quadruple Inductively Coupled Plasma/Mass Spectrometry (ICP-MS/MS).

Interpretation

• Increased manganese levels are seen in acute hepatitis and myocardial infarction.
• Decreased levels are seen in seizure disorders, maple syrup urine disease, phenylketonuria, and in certain patients with bone and joint malformations. A true deficiency state (due to decreased intake) has not been described for manganese.
• Toxicity results primarily from inhalation of particulate material containing high levels of manganese. Manganese toxicity occurs in miners, foundry workers, welders, pharmaceutical workers, pottery and ceramics makers, varnish manufacturers, and in makers of food additives.
• Elevated results from non-certified trace element-free collection tubes may be due to contamination. Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as a Royal Blue-top sterile tube (no additive).

Clinical Utility

This assay is used to detect toxic manganese exposure, especially neurological syndromes and movement disorders. It is also used to follow manganese therapy in parental nutrition especially in patients with liver disease or that have excessive gastrointestinal losses.

CPT Codes

83785

Contacts

Last Updated

11/3/2023