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Hypersensitivity Pneumonitis II

Test Codes

EPIC: LAB6067, Beaker: XHYP2, ARUP: 3001560

Department

Send Outs

Instructions

This panel includes:

• Aspergillus flavus Antibody
• Aspergillus fumigatus #2 Antibody
• Asperigillus fumigatus #3 Antibody
• Saccharomonospora viridis Antibody
• Thermoactinomyces candidus Antibody

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.2 mL)

Rejection Criteria

• Plasma
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.2 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 48 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday – Friday.
Results available in 4-6 days.

Reference Range

Aspergillus flavus Antibody: None detected.
Aspergillus fumigatus #2 Antibody: None detected.
Asperigillus fumigatus #3 Antibody: None detected.
Saccharomonospora viridis Antibody: None detected.
Thermoactinomyces candidus Antibody: None detected.

Test Methodology

Qualitative Immunodiffusion.

Interpretation

Precipitating antibodies against the offending antigen can be demonstrated in most active cases of hypersensitivity pneumonitis. However, a positive test does not always indicate active disease since asymptomatic individuals may develop precipitins without any features of hypersensitivity. A positive test is a helpful diagnostic tool when supported by historical and clinical evidence. The absence of a positive test does not rule out hypersensitivity pneumonitis.

Analyte Specific Reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration approval. This test was developed and its performance characteristics determined by ARUP Laboratories, Inc. It has not been approved by the U.S. Food and Drug Administration. This test should not be regarded as investigational or for research use.

Clinical Utility

This assay aids in the diagnosis of hypersensitivity pneumonitis.

CPT Codes

86331 x2, 86606 x3.

Contacts

Last Updated

9/18/2023