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Filaria IgG4 Antibodies

Test Codes

EPIC: LAB1231448, Beaker: XFILIGG4, MAYO: FFAG4

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 0.2 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.1 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 0.2 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.1 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN. Forwarded to Quest Diagnostics Infectious Disease, Cypress, CA.

Performed

Wednesday.
Results available in 1-3 weeks.

Reference Range

By report.

Test Methodology

Immunoassay.

Clinical Utility

This quantitative assay uses Brugia malayi microfilaria antigen to detect filaria-specific IgG and IgM antibodies. Detection of B. malayi-specific total IgG is highly sensitive but is not specific due to the cross-reactivity with other helminths or certain protozoa that share a common antigen of phosphocholine (PC). Detection of filarial IgM and a significant rise in filarial IgG antibody between an acute (drawn at the onset of illness) and convalescent (drawn 3-6 weeks later) specimen is the best evidence of a recent infection. Detection of B.malayi-reactive IgG4 improves the specificity of detection of filarial antibodies.

CPT Codes

86682

Contacts

Last Updated

10/24/2024