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Fibrinogen Antigen, Plasma

Immunologic Fibrinogen, Factor I Antigen

Test Codes

EPIC: LAB6260, Beaker: XMISC, Mayo: FIBAG

Department

Send Outs

Specimen Collection Criteria

Collect: One Light Blue-top Sodium Citrate tube.

Physician Office/Draw Specimen Preparation

Centrifuge to separate plasma from cells. Transfer plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Rejection Criteria

• Hemolyzed, icteric, lipemic specimens.
• Specimens that are not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate plasma from cells. Transfer plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Monday – Saturday.
Results available in 2-3 days.

Reference Range

By report.

Test Methodology

Immunoturbidimetric.

Clinical Utility

• Fibrinogen Antigen assay measures the amount of fibrinogen that is present, not the activity of the fibrinogen. Discrepancies between the amount of fibrinogen antigen and the activity can aid in the diagnosis of dysfibrinogenemias. Patients with a decreased fibrinogen activity, but normal fibrinogen antigen, produce fibrinogen that does not function normally in the clotting mechanism, i.e. dysfibrinogenemia.
  
• Congenital dysfibrinogenemias are most often inherited in an autosomal dominant or codominant fashion. Several variants are inherited autosomal recessively. Acquired dysfibrinogenemias occur in severe liver disease. The fibrinogen molecule produced by the impaired liver is not functional or able to form a stable fibrin clot.

CPT Codes

85385

Contacts

Last Updated

7/21/2024