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Diabetes Mellitus Type 1 Evaluation, Serum

Insulin Antibodies, Islet-cell Antibodies, GAD65 Antibody, Zinc Transporter 8 Antibody, Diabetes Autoimmune Test Group

Test Codes

EPIC: LAB1230658, Beaker: Diab Type, MAYO: DBS1

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): Two Gold-top SST tubes.
Also acceptable: Two plain Red-top tubes.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within one hour of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 4.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 2.0 mL)

Rejection Criteria

• Hemolyzed, icteric, or lipemic samples.
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within one hour of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 4.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 2.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Varies.
Results available in 7-11 days.

Reference Range

By report.

Test Methodology

ELISA and Radioimmunoassay.

Clinical Utility

Antibodies to insulin and pancreatic proteins may be used to differentiate type 1 and type 2 diabetes. Radioimmunoprecipitation assays with recombinant antigens assure assay sensitivity and specificity. Testing for multiple markers increases diagnostic sensitivity to 98% and increases positive predictive value of the tests.

CPT Codes

86337, 86341 x3.

Contacts

Last Updated

10/22/2024