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Spironolactone

Aldactone, Aldactazide, Canrenone

Test Codes

NMS: 4207, Order as a Miscellaneous Send Out.

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavender-top EDTA tube. (Minimum: 0.7 mL)

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose. 

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum or plasma from cells. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.4 mL)

Rejection Criteria

• Specimens collected in SST tubes.
• Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate serum or plasma from cells. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.4 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 2 days
Refrigerated (2-8°C or 36-46°F): 1 month
Frozen (-20°C/-4°F or below): 24 months

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT, forwarded to National Medical Services (NMS), Willow Grove, PA.

Performed

Tuesday.
Results available in 5-10 days.

Reference Range

By report.

Test Methodology

High-Performance Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS).

Interpretation

Spironolactone is a mild diuretic agent. Spironolactone is used to treat edema, particularly that due to cirrhosis of the liver, and to treat hypertension.

Clinical Utility

This assay is used for the therapeutic monitoring and toxicity assessment of spironolactone and it's metabolite (canrenone).

CPT Codes

80375

Contacts

Last Updated

10/3/2023