Lab Test

Soluble Transferrin Receptor, Serum


Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.  (Minimum Whole Blood: 2.0 mL) 

Also acceptable: One plain Red-top tube. (Minimum Whole Blood: 2.0 mL)

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30 – 60 minutes then centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube prior to transport. (Minimum Serum: 0.5 mL) 

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5mL).

Rejection Criteria

  • Plasma specimens.
  • Severely hemolyzed, lipemic or icteric specimens.


Tuesday, Friday.
Results available within 3 business days.

Reference Range

12.2-27.3 nmol/L

Test Methodology

Chemilunimescent Enzyme immunoassay.

Test Background

The soluble transferrin receptor (sTfR) is a soluble truncated form of the transferrin receptor. sTfR levels rise significantly as the iron level in tissue decreases, and the demand for iron increases because of expansion of the erythroid marrow. Measurement of ferritin is used for the diagnosis of iron deficiency. However, since ferritin is an acute phase reactant, it can be elevated in hospitalized or acutely ill patients. sTfR is not an acute phase reactant, and therefore may be useful in evaluating patients suspicious for iron deficiency in which ferritin concentration does not correlate with iron status. This can occur in patients with inflammatory conditions or chronic diseases.

Clinical Utility

This assay aids in the diagnosis of iron deficiency anemia.

CPT Code


Test Codes


Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.