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Plasminogen Activator Inhibitor Genotyping (Southeast Michigan Only)

Test Codes

EPIC: LAB1231237, Beaker: XPAI1G, ARUP: 2004980

Department

Send Outs

Specimen Collection Criteria

Collect: One Lavender-top EDTA tube. (Minimum: 1.0 mL)
Also acceptable: One Yellow-top ACD tube. 

Physician Office/Draw Specimen Preparation

Do not centrifuge. Maintain whole blood refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: Whole blood refrigerated (2-8°C or 36-46°F). Minimum: 1.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

Storage

Whole Blood
Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 1 week
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday, Thursday
Results available in 8-11 days.

Reference Range

By report.

Test Methodology

Polymerase Chain Reaction (PCR)/ Fluorescence.

Interpretation

The PAI-1 promoter 4G/5G polymorphism located in the promoter region of the SERPINE1 gene.

Clinical Utility

The 4G allele within in the promoter region of the PAI-1 (SERPINE1) gene is associated with higher plasma PAI-1 activity when compared with the 5G allele. Heterozygosity or homozygosity for the 4G allele confers a risk for venous thromboembolism (VTE), especially in individuals with other thrombophilic risk factors, as well as a risk for myocardial infarction. 

CPT Codes

81400

Contacts

Last Updated

11/12/2024