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Paraneoplastic Autoantibody Evaluation, CSF

Test Codes

EPIC: LAB1230344, MAYO: PAC1

Department

Send Outs

Specimen Collection Criteria

Collect: 4.0 mL cerebrospinal fluid in a sterile collection container. (Minimum: 2.0 mL)

Physician Office/Draw Specimen Preparation

Maintain specimens refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: 4.0 mL cerebrospinal fluid, refrigerated (2-8°C or 36-46°F). (Minimum: 2.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Maintain specimens refrigerated (2-8°C or 36-46°F) prior to transport.

Transport: 4.0 mL cerebrospinal fluid, refrigerated (2-8°C or 36-46°F). (Minimum: 2.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Varies
Results available in 9-12 days.

Reference Range

By report.

Test Methodology

Indirect Immunofluorescence Assay, Western Blot, Immunoblot, Radioimmunoassay, Cell-Binding Assay

Interpretation

By report.

Clinical Utility

Aids in the diagnosis of paraneoplastic neurological autoimmune disorders related to carcinoma of lung, breast, ovary, thymoma, or Hodgkin lymphoma in spinal fluid specimens.

Several antineuronal and glial autoantibodies are recognized clinically as markers of a patient's immune response to specific cancers (paraneoplastic autoantibodies). Seropositive patients present with neurologic symptoms and signs in more than 90% of cases. The cancers are most commonly small-cell lung carcinoma, ovarian (or related mullerian) carcinoma, breast carcinoma, thymoma, or Hodgkin lymphoma. The cancers may be new or recurrent, are usually limited in metastatic volume, and are often occult by standard imaging procedures. Detection of the informative marker autoantibodies allows early diagnosis and treatment of the cancer, which may lessen neurological morbidity and improve survival.

CPT Codes

86255 x 9

Add the following as appropriate for reflexes/confirmations performed:

84182-AGNBC
86255-AMPCC
86256-AMPIC
84182-AMIBC
84182-AN1BC
84182-AN2BC
86255-CS2CC
84182-CRMWC
86255-DPPCC
86256-DPPTC
86255-DPPIC
86255-GABCC
86256-GABIC
86341-GD65C
86255-LG1CC
86255-GL1CC
86256-GL1TC
86255-GL1IC
86255-NMDCC
86256-NMDIC
84182-PC1BC
84182-PCTBC
83519-VGKCC

LOINC:  69048-7, WBLOT 53715-9

Contacts

Last Updated

11/8/2024