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Oxcarbazepine Metabolite Level

Monohydroxycarbazepine, MHD, Oxcarbazepine, Trileptal, Oxcarbazepine metabolite (Monohydroxycarbazepine, MHD)

Test Codes

Antrim #19124, EPIC: LAB5407, SOFT: OXCMT

Department

Toxicology

Specimen Collection Criteria

Collect: One plain Red-top tube. (Minimum Whole Blood: 1.0 mL)

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.
Record the exact time of specimen collection on the tube or in the computer system.

Physician Office/Draw Specimen Preparation

Let specimens clot 30-60 minutes. Centrifuge specimen to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within two hours of collection. (Minimum: 1.0 mL blood)

Preparation for Courier Transport

Transport: Collection tube, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL blood)

Rejection Criteria

• Serum Separator (SST) tubes.
• Severely lipemic or hemolyzed specimens. 

In-Lab Processing

Let specimens clot 30-60 minutes. Centrifuge specimen to separate serum from cells. Deliver an aliquot of serum or the collection tube immediately to the appropriate testing station.

 immediately to the appropriate testing station.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Frozen (-20°C/-4°F or below): 1 month

Laboratory

Royal Oak Toxicology Laboratory

Performed

Sunday – Saturday.
Results available the same day as testing performed.

Reference Range

Therapeutic Range: 10-30 mcg/mL (MHD, Monohydroxycarbazepine).
MHD Concentrations greater than 50 mcg/mL will be called.

Test Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS).

This test was developed and its performance characteristics determined by Beaumont Health. It has not been cleared or approved by the FDA. The Laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.

Interpretation

Oxcarbazepine is metabolized to an active metabolite, Monohydroxycarbazepine. 

Clinical Utility

Trileptal® (oxcarbazepine) is an antiepileptic drug. It is indicated for use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy. This assay is used for the therapeutic monitoring and toxicity assessment of Trileptal. 

CPT Codes

80183
LOINC: 31019-3

Contacts

Last Updated

1/25/2023