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Mycoplasma IgG (Southeast Michigan Only)

Mycoplasma (IgG), Mycoplasma pneumoniae IgG

Test Codes

EPIC: LAB12310396, SOFT: MYCGG, Antrim #30942

Department

Immunology

Specimen Collection Criteria

Collect: One Gold-top SST tube. (Minimum Whole Blood: 2.0 mL)

Physician Office/Draw Specimen Preparation

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL)

Rejection Criteria

• Plasma specimens.
• Severely hemolyzed, lipemic or icteric specimens. 

In-Lab Processing

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Room temperature is acceptable for a maximum of two hours. (Minimum Serum: 0.5 mL)

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers^® with Separator Gel
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers^® without Separator Gel
Room Temperature (20-25°C or 68-77°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Chemistry Laboratory

Performed

Tuesday, Thursday.
Results available in 3 business days.

Reference Range

Less than 0.91: Negative.
0.91 - 1.09: Equivocal.
Greater than 1.09: Positive.

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA).

Interpretation

Mycoplasma IgG is first detectable 10-21 days after the onset of symptoms. Mycoplasma IgG testing early in the disease may yield false-negative results. IgG antibody levels can persist for months to years. Therefore, the presence of mycoplasma IgG in a single sample cannot be used as an indicator of recent infection.

Clinical Utility

Mycoplasma IgG tests are used to provide serological evidence of past M. pneumoniae infections. Negative results do not rule out the presence of M. pneumoniae-associated disease. If testing is performed too early following primary infection, IgG and/or IgM may not be detectable. If a M. pneumoniae infection is clinically indicated, a second specimen should be submitted at least 2 weeks later.

Clinical Disease

M. pneumoniae is primarily a respiratory tract pathogen that involves the nasopharynx, throat, trachea, bronchi, bronchioles, and alveoli. M. pneumoniae accounts for approximately 20% of all cases of pneumonia. Infected patients present with an insidious onset of fever, malaise, headache, and nonproductive cough. The frequency and severity of the cough often increases over 1–2 days and may eventually become debilitating. Most infections are self-limiting and are rarely fatal. However serious cardiovascular, dermatologic, and central nervous system complications have been described.

Epidemiology

Mycoplasma infections occur throughout the year, especially in temperate climates. Symptomatic infections occur most commonly in children and young adults (ages 2-19 years).

Incubation Period

The incubation period is 2–3 weeks (average = 15 - 25 days).

Transmission

M. pneumoniae is spread from patient to patient via respiratory droplets produced by coughing.

CPT Codes

86738
LOINC:  6481-6

Contacts

Last Updated

11/6/2024