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Lysozyme (Muramidase), Plasma

Muramidase

Test Codes

EPIC: LAB1230807, Beaker: Lysozyme, MAYO: MURA

Department

Send Outs

Specimen Collection Criteria

Collect (preferrred): One Pink-top (K₂EDTA) tube.

Also Acceptable:  One Lavender-top (EDTA) tube.

Send specimen for processing immediately after collection.

Physician Office/Draw Specimen Preparation

Critical frozen. Centrifuge to separate plasma from cells immediately. Transfer plasma to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Preparation for Courier Transport

Transport: 2.0 mL plasma, frozen (-20°C/-4°F or below). (Minimum: 1.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Critical frozen. Centrifuge to separate plasma from cells immediately. Transfer plasma to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Transport: 2.0 mL plasma, frozen (-20°C/-4°F or below). (Minimum: 1.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Monday – Friday.
Results available in 3-6 days.

Reference Range

By report.

Test Methodology

Turbidimetric.

Interpretation

Levels greater than 200 mcg / mL may be seen in acute nonlymphocytic leukemia (M2, M4, M5) or chronic granulocytic leukemias.

Clinical Utility

Lysozyme levels may be elevated in acute myelomonocytic leukemia (FAB-M4), chronic myelomonocytic leukemia (CMML) and chronic myelocytic leukemia (CML). Increased serum lysozyme activity is present in tuberculosis, sarcoidosis, megaloblastic anemias, acute bacterial infections, ulcerative colitis, regional enteritis and Crohn's disease. Elevated levels of lysozyme occur during severe renal insufficiency, renal transplant rejection, urinary tract infections, pyelonephritis, glomerulonephritis and nephrosis.

CPT Codes

85549

Contacts

Last Updated

11/4/2024