Lab Test

Lithium Level, Serum

Antrim #15960, EPIC: LAB5400, SOFT: LITHI

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Time of Collection: Trough, just prior to the next dose.
Record the exact time of specimen collection on the tube or in the computer system.

Physician Office/Drawsite Specimen Preparation

Let specimens clot 30-60 minutes and refrigerate (2-8°C or 36-46°F) the collection tube within two hours of collection. (Min: 1.0 mL blood)

Preparation for Courier Transport

Transport: Collection tube, refrigerated (2-8°C or 36-46°F). (Min: 1.0 mL blood)

Rejection Criteria

  • Severely lipemic or hemolyzed specimens.

Storage

Centrifuged SST tubes and Microtainers® with separator gel may be transported and stored at room temperature (up to 25oC or 77oF) for 2-4 hours. DO NOT FREEZE TUBES CONTAINING WHOLE BLOOD. For longer storage, the specimen should be refrigerated (2o-8oC).
Red-top tubes and Microtainers® without separator gel may be stored at room temperature for up to 2 hours. DO NOT FREEZE TUBES CONTAINING WHOLE BLOOD. For longer storage, the serum should be removed from the clot and refrigerated (2o-8oC).

Serum specimens or (pour-overs) may be stored at room temperature (up to 25oC or 77oF) for 2-4 hours. For longer storage the sample should be refrigerated (2o to 8oC; 36o to 47o F) for one week.

Performed

Sunday - Saturday, 24 hours a day.
STAT results available within 1 hour of receipt in the Laboratory.
Routine results available within 24 hours.

Reference Range

Therapeutic Range: 0.6-1.2 mmol/L
Critical Range: Greater than 1.5 mmol/L

Test Methodology

Grosse Pointe: Direct Potentiometry.
Royal Oak and Troy: Colorimetric.

Interpretation

Lithium is used for the treatment of manic-depressive illness. Values of greater than 1.5 mmol/L indicates an increased risk of intoxication. Severe intoxication, characterized by muscle rigidity, hyperactive deep tendon reflexes, and epileptic seizures, is usually associated with lithium concentrations greater than 2.5 mmol/L. Lithium is eliminated renally. Lithium can cause renal toxicity, thereby inhibiting its own elimination.

Clinical Utility

This assay is used to monitor the therapeutic drug level and evaluate the toxicity of lithium.

CPT Code

80178.

Test Codes

Antrim #15960, EPIC: LAB5400, SOFT: LITHI

Last Updated

7/11/2019

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

 

This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.