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Lidocaine Level

Xylocaine

Test Codes

Anrim #17245, EPIC: LAB685, SOFT: LIDOC

Department

Toxicology

Specimen Collection Criteria

Collect: One plain Red-top tube. (Minimum Whole Blood: 1.0 mL)

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.
Record the exact time of specimen collection on the tube or in the computer system.

Physician Office/Draw Specimen Preparation

Let specimens clot 30-60 minutes. Refrigerate (2-8°C or 36-46°F) the collection tube within two hours of collection. (Minimum: 2.0 mL blood)

Preparation for Courier Transport

Transport: Collection tube, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL blood)

Rejection Criteria

• Serum Separator (SST) tubes.
• Severely lipemic or hemolyzed specimens. 

In-Lab Processing

Let specimens clot 30-60 minutes. Centrifuge specimen to separate serum from cells. Deliver an aliquot of serum or the collection tube immediately to the appropriate testing station.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Frozen (-20°C/-4°F or below): 1 month

Laboratory

Royal Oak Toxicology Laboratory

Performed

Sunday – Saturday, 24 hours a day.
STAT results available within 2 hours of receipt in the Laboratory.
Routine results available within 24 hours.

Reference Range

Therapeutic Range: 2-5 mcg/mL.
Critical Range: Greater than 7 mcg/mL.

Test Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS).

This test was developed and its performance characteristics determined by Beaumont Health. It has not been cleared or approved by the FDA. The Laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.

Interpretation

Long term Lidocaine infusions exhibit time-dependent decreases in clearance. Serum concentrations may achieve higher levels than predicted.

Clinical Utility

Lidocaine is used as a local anesthetic and to treat ventricular arrhythmias, primarily during heart surgery or after a myocardial infarction. This assay is used to monitor the therapeutic drug level and evaluate the toxicity of lidocaine.

CPT Codes

80176
LOINC: 3714-3

Contacts

Last Updated

7/21/2024