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JC Polyoma Virus Quantitative PCR, Serum

JC Virus (JCV) DNA Detection, JC Polyoma Virus DNA, Real-Time PCR

Test Codes

EPIC: LAB1230164, Viracor: 3500

Department

Send Outs

Specimen Collection Criteria

Collect: One Red-top Tube

Physician Office/Draw Specimen Preparation

Centrifuge blood specimens to separate serum from cells. Transfer serum to a plastic transport tube and room temperature (20-26°C or 68-78.8°F). 

Preparation for Courier Transport

Transport: 2.0 mL serum, room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5 mL)

Rejection Criteria

• Specimens not collected or processed as indicated.
• Gel separator tube- gold SST.
• Grossly hemolyzed specimen.

In-Lab Processing

Centrifuge blood specimens to separate serum from cells. Transfer serum to a plastic transport tube and room temperature (20-26°C or 68-78.8°F). 

Transport: 2.0 mL serum, room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 4 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unavailable

Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

 

Laboratory

Sent to Eurofin/Viracor Laboratory in Lenexa, KS.

Performed

Monday-Saturday.
Results available in 1-3 days. 

Reference Range

By report.

Test Methodology

Quantitative Polymerase Chain Reaction

Interpretation

By report.

Clinical Utility

CV is the etiologic agent of progressive multifocal leukoencephalopathy (PML) which is mainly seen in HIV patients, organ transplant patients, and other immunodeficient syndromes. In addition to PML, JCV also causes nephropathy in the renal transplant setting, although with considerably less frequency than BKV. JCV should always be considered in an immunocompromised patient with progressively deteriorating CNS function. Quantitative JCV DNA PCR can be used to detect JCV in CSF in the setting of CNS disease, and blood and urine in the setting of renal dysfunction. Quantitative DNA PCR can be used to track the course of infection as well as monitor response to treatment.

CPT Codes

87799

Contacts

Last Updated

8/23/2024