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Interleukin 2 Receptor (CD25), Soluble

Interleukin-2 Receptor, Interleukin 2 Receptor by MAFD, CD25, IL2

Test Codes

EPIC: LAB1230002, Beaker: XIN2R, ARUP: 51529

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.

Also acceptable: One plain Red-top tube.

• Critical frozen. Send specimens for processing immediately after collection.
• Separate samples must be submitted when multiple tests are ordered.

Physician Office/Draw Specimen Preparation

Critical frozen. Centrifuge to separate serum from cells within two hours of collection. Transfer serum into a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Preparation for Courier Transport

Transport: 1.0 mL serum, frozen (-20°C/-4°F or below). (Minimum: 0.4 mL)

Rejection Criteria

Specimens not collected and processed as indicated. 

Inpatient Specimen Preparation

Critical frozen. Deliver specimen to the Laboratory immediately for processing.

In-Lab Processing

Critical frozen. Centrifuge to separate serum from cells within two hours of collection. Transfer serum into a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Transport: 1.0 mL serum, frozen (-20°C/-4°F or below). (Minimum: 0.4 mL) 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 30 minutes
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Sunday – Saturday.
Results available in 2-5 days.

Reference Range

175.3 pg/mL – 858.2 pg/mL

Test Methodology

Quantitative Multiplex Bead Assay.

Interpretation

The performance characteristics of this test were validated by ARUP. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test "for Research use only, not for clinical use."

Clinical Utility

The receptor of the cytokine interleukin 2 (IL-2) plays a crucial role in the regulation of the immune response. Binding of IL-2 to the receptor (IL2R) on the surface of T-lymphocytes triggers a series of intracellular signals that result in activation and proliferation of resting T cells. Research has found sIL2R is present in elevated levels with neoplastic diseases, autoimmune diseases, organ allograft rejection and different infections. It appears the sIL2R is an indicator of a wide spectrum of disorders involving immune activation.

Cytokine levels may demonstrate diurnal variation. For longitudinal comparison, it is recommended that cytokine levels be determined at the same time of day.

CPT Codes

83520

Contacts

Last Updated

11/1/2024