Insulin Like Growth Factor Binding Protein 3
IGF Binding Protein 3, IGFBP3 , EPIC: LAB7118, SOFT: IGFP3
Specimen Collection Criteria
Collect (preferred specimen): One Gold-top SST tube.
Physician Office/Drawsite Specimen Preparation
Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within eight hours of collection. (Minimum Serum: 0.5 mL)
Preparation for Courier Transport
Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL)
- Lipemic or icteric specimens.
- Grossly hemolyzed specimens.
Ambient: 8 hours
Refrigerated: 24 hours
Frozen: 1 year
Monday - Friday.
Results available within 2 business days.
65 years and older
Tanner Stage I
Tanner Stage II
Tanner Stage III
Tanner Stage IV & V
Insulin-like growth factors 1 and 2 (IGF-1, IGF-2) are small polypeptides involved in the regulation of cell growth. IGF-1 and IGF-2 are bound to insulin-like growth factor binding proteins, six of which have been described. IGFBP-3 is the predominant of these, binding ~95% of circulating IGF-1 and IGF-2.
IGF-1 serves as the major mediator of the anabolic and growth-promoting effects of growth hormone. Secretion patterns of IGF-1 and IGFBP-3 mirror each other, and are primarily growth hormone dependent. In contrast to growth hormone production, which is pulsatile and demonstrates significant diurnal variation, IGF-1 and IGFBP-3 levels exhibit only minor fluctuations. Given that, serum measurements of IGF-1 and IGFBP-3 represent a more stable assessment of growth hormone production, and aid in the evaluation of growth disorders and growth hormone deficiency.
EPIC: LAB7118, SOFT: IGFP3
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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.