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Hypersensitivity Pneumonitis I

Test Codes

EPIC: LAB6066, Beaker: XHYP1, ARUP: 55076

Department

Send Outs

Instructions

This panel includes:

• Aspergillus fumigatus #1 Antibodies
• Aspergillus fumigatus #6 Antibodies
• Aureobasidium pullulans Antibodies
• Pigeon serum Antibodies
• Micropolyspora faeni Antibodies
• Thermoactinomyces vulgaris #1 Antibodies

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.15 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.15 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 48 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Sunday – Saturday.
Results available in 4-6 days.

Reference Range

Aspergillus fumigatus #1 Antibodies: None detected.
Aspergillus fumigatus #6 Antibodies: None detected.
Aureobasidium pullulans Antibodies: None detected.
Pigeon serum Antibodies: None detected.
Micropolyspora faeni Antibodies: None detected.
Thermoactinomyces vulgaris #1 Antibodies: None detected.

Test Methodology

Qualitative Immunodiffusion.

Interpretation

Precipitating antibodies against the offending antigen can be demonstrated in most active cases of hypersensitivity pneumonitis, however, a positive test does not always indicate active disease since asymptomatic individuals may develop precipitins without any features of hypersensitivity. A positive test is a helpful diagnostic tool when supported by historical and clinical evidence. The absence of a positive test does not rule out hypersensitivity pneumonitis.

Clinical Utility

This assay aids in the diagnosis of hypersensitivity pneumonitis.

CPT Codes

86331x4, 86606x2.

Contacts

Last Updated

10/2/2023