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Hantavirus Hantaan IgG and IgM Antibodies

Test Codes

EPIC: LAB6264, Beaker: XMISC, Mayo: FHVGM

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN, forwarded to Quest Diagnostics Infectious Disease San Juan, Capistrano, CA.

Performed

Monday, Wednesday, Saturday.
Results available in 3-8 days.

Reference Range

By report.

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA).

Interpretation

Detection of specific IgM in a single serum is consistent with acute infection. IgM may appear as early as three days after disease and persists for several weeks.

Specific IgG antibodies are detected during the first 2-3 weeks after disease onset and remain elevated for years.

Demonstration of seroconversion or a significant increase of specific IgG antibodies (convalescent/acute ratio of greater than 1.5) is suggestive of acute infection.

Sera containing antibodies against the PUU serotype often cross-react with HTN serotype; however , comparison of results for PUU and HTN IgM antibodies in the same sample often allow identification of the infection Hantavirus serotype, which is of important prognostic value.

Paired testing of acute and convalescent phase sera (taken 2-3 weeks apart) is recommended if clinically indicated.

Clinical Utility

This assay is used in the serological diagnosis of Hantavirus infections. This assay detects specific IgG and IgM antibodies to Hantavirus including serotype Hantaan (HTN).

Clinical Disease

Hantavirus serotype Hantaan is part of a larger group of arboviruses responsible for a complex of diseases called hemorrhagic fever with renal syndrome (HFRS). The severe form of HFRS is caused by HTN serotype and the mild form is caused by Puumala (PUU) serotype.

CPT Codes

86790x2.

Contacts

Last Updated

7/21/2024