Lab Test

DHEA (Dehydroepiandrosterone), Serum

DHEA , MAYO: DHEA, EPIC: LAB6000, SOFT: XDHEA

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.

Send specimen for processing immediately after collection.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 1.0 mL serum, frozen (-20°C/-4°F or below). (Min: 0.45 mL)

Rejection Criteria

  • Grossly hemolyzed specimens.
  • Grossly lipemic specimens.
  • Specimens not collected and processed as indicated.

Performed

Monday - Friday.
Results available 3-7 days.

Reference Range

By report.

Test Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

Interpretation

Patients with Cushing's disease may have increased DHEA and increased cortisol levels, and patients with congenital adrenal hyperplasia may have increased DHEA level and decreased cortisol level. However, DHEA currently has not been established for the purpose of differential diagnosis.

Administration of ACTH increases DHEA secretion. Administration of corticosteroids decreases DHEA.

Clinical Utility

Elevated plasma DHEA concentrations are suggestive of a heterozygous form of 21-hydroxylase deficiency. Patients with hyperandrogeny of adrenal origin often have an elevated DHEA: androstenedione ratio.

CPT Code

82626.

Test Codes

MAYO: DHEA, EPIC: LAB6000, SOFT: XDHEA

Last Updated

7/11/2019

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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.