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Clonazepam Level

Klonopin, Clonopin

Test Codes

EPIC: LAB5383, Warde: CLONA, Beaker: XCLONAZ

Department

Send Outs

Specimen Collection Criteria

Collect: One plain Red-top tube.
Acceptable: One Lavender-top EDTA.

Do not use Serum Separator Tubes.

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum or plasma from cells. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.3 mL)

Rejection Criteria

Serum Separator (SST) tubes.

In-Lab Processing

Centrifuge to separate serum or plasma from cells. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.3 mL) 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 48 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Frozen (-20°C/-4°F or below): 1 month 

Laboratory

Sent to Warde Medical Laboratory, Ann Arbor, MI.

Performed

Varies.
Results available 3-4 days.

Reference Range

Therapeutic Range: 15-60 ng/mL.
Toxic Range: Greater than 80 ng/mL.

Test Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS).

Interpretation

The primary value of Clonazepam monitoring may be in insuring that patients achieve sufficient serum levels to assure an adequate clinical trial. It may also be valuable in evaluating symptoms of CNS toxicity.

Clinical Utility

This assay is used to monitor the therapeutic drug level and evaluate the toxicity of clonazepam. Clonazepam is a long-acting benzodiazepine. It is used in epilepsy both in prophylaxis when other agents have failed and in status epilepticus utilizing intravenous administration. It is increasingly used in psychiatry as a treatment for panic disorder.

CPT Codes

80346 (alternate: G0480).
LOINC: 3494-2, Last Dose Date  29742-4, Last Dose Time  29637-6

Contacts

Last Updated

8/16/2023