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BUN (Blood Urea Nitrogen)

Blood Urea Nitrogen

Test Codes

EPIC: LAB140, Beaker: BUN

Department

Toxicology

Specimen Collection Criteria

FOR EC AND INPATIENT SAMPLE COLLECTION ONLY:

Preferred Sample:  One Light Green (Mint) Top or Dark Green with Yellow Ring Plasma Separator Tube (PST). (Minimum Whole Blood: 4.0 mL) 

Acceptable Sample:  One Gold Top SST (Minimum Whole Blood: 4.0 mL) 

FOR PHYSICIAN OFFICE/OUTREACH SAMPLE COLLECTION:

COLLECT:  One Gold Top SST (Minimum Whole Blood:  4.0 mL) 

Contact Laboratory for acceptability of other tube types.
See Minimum Pediatric Specimen Requirements for Microtainer^® collection.

Physician Office/Draw Specimen Preparation

Let SST specimens clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged SST tube within two hours of collection. (Minimum: 0.5 mL)

Preparation for Courier Transport

Transport: Centrifuged SST tube, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Rejection Criteria

Moderate to grossly hemolyzed specimens.

Red-top tubes with serum not separated from cells within two hours of collection.

In-Lab Processing

Let SST specimens clot 30-60 minutes. Centrifuge SST tubes and Microtainers^® to separate serum from cells. Deliver immediately to the appropriate testing station.

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers^® with Separator Gel
Room Temperature (20–26°C or 68–78.8°F): 2-4 hours
Refrigerated (2–8°C or 36–46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers^® without Separator Gel
Room Temperature (20–26°C or 68–78.8°F): 2-4 hours
Refrigerated (2–8°C or 36–46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20–26°C or 68–78.8°F): 2-4 hours
Refrigerated (2–8°C or 36–46°F): 7 days
Frozen (-20°C/-4°F or below): 7 days

Specimen Storage in Department Prior to Disposal:

Refrigerated (2–8°C or 36–46°F): 7 days

Laboratory

Canton Chemistry Laboratory
Dearborn Chemistry Laboratory
Farmington Hills Chemistry Laboratory 
Grosse Pointe Chemistry Laboratory 
Lenox Main Laboratory
Royal Oak Automated Chemistry Laboratory 
Troy Chemistry Laboratory
Taylor Chemistry Laboratory
Trenton Chemistry Laboratory
Wayne Chemistry Laboratory 

Performed

Sunday – Saturday, 24 hours a day.
STAT results available within 1 hour of receipt in the Laboratory.
Routine results available within 4 hours.

Reference Range

Age related reference range:

Age	Range (mg/dL)
0 – 14 days	3–23
15 days – <1 year	3–17
1 – 10 years	9–22
11 – 18 years	7–21
19 years – Adult	7–25

Test Methodology

Enzymatic Urease.

Interpretation

• Increased BUN may be due to decreased renal perfusion (pre-renal causes such as congestive heart failure, dehydration, or increased protein catabolism), intrinsic renal disease, either acute or chronic, post-renal obstruction or high protein diet.
• Decreased BUN is seen in low protein and high carbohydrate diets, increased utilization for protein synthesis (pregnancy, infancy, acromegaly) severe liver damage and impaired absorption (celiac disease).

Clinical Utility

The BUN assay is frequently requested in conjunction with the serum creatinine test for the differential diagnosis of prerenal (cardiac decompensation, water depletion, increases protein catabolism), renal (glomerulonephritis, chronic nephritis, polycystic kidney, nephrosclerosis, tubular necrosis), and postrenal (obstructions of the urinary tract) hyperuremia.

CPT Codes

84520
LOINC: 3094-0

Contacts

Last Updated

7/21/2024