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Anti-Mullerian Hormone

Test Codes

EPIC: LAB1230502, Beaker: XAMH

Note: Due to no weekend delivery. Specimens received in lab between Friday and Sunday will not be sent out until Monday.

Department

Send Outs

Instructions

Ordering instructions:

• AMH is only validated at Spectrum Health on female patients 18 and older.
• Samples should be drawn pm 2-4 day of the menstrual cycle.

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.

Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot completely then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 2.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot completely then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 2.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 72 hours
Frozen (-20°C/-4°F or below): Freeze for longer storage

Specimen Storage in Department Prior to Disposal: 72 hours

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Corewell Health Reference Laboratory, Grand Rapids, MI.

Performed

Sunday – Saturday.
Results available in 1 day.

Reference Range

Test Methodology

Electrochemiluminescence Immunoassay.

Interpretation

While the optimal AMH concentrations for predicting response to in vitro fertilization are still being established, it is accepted that AMH concentrations in the perimenopausal to menopausal range indicate minimal to absent ovarian reserve. Depending on patient age, ovarian stimulation is likely to fail in such patients by contrast, if serum AMH concentrations exceed 3 ng/mL, hyper-response to ovarian stimulation may result. For these patients, a minimal stimulation would be recommended.

In patients with polycystic ovarian syndrome, AMH concentrations may be 2- to 5-fold higher than age-appropriate reference range values. Such high levels predict anovulatory and irregular cycles.

In children with intersex conditions, an AMH result above the normal female range is predictive of the presence of testicular tissue, while an undetectable value suggests its absence.

In boys with cryptorchidism, a measurable AMH concentration is predictive of undescended testes.

Granulosa cell tumors of the ovary may secrete AMH. Levels should fall with successful treatment. Rising levels indicate tumor recurrence or progression.

AMH measurement alone is seldom sufficient for diagnosis and results should be interpreted in light of clinical findings and other relevant test results.

Clinical Utility

• Assessment of ovarian function.
• Is part of the workup for infertility.
• Assessment of intersex conditions.
• Evaluation for polycystic ovarian syndrome.

CPT Codes

83520

Contacts

Last Updated

7/21/2024