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Anti-Beta 2-Glycoprotein I Antibodies (IgG, IgM)

Anti-Beta-2 glycoprotein I Antibodies, Beta-2 glycoprotein I Antibodies, Anti Beta 2 glycoprotein I Antibodies IgG, IgM

Test Codes

EPIC: LAB1230554, Beaker: B2GLY, Antrim #32033

Department

Immunology

Specimen Collection Criteria

Collect: One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8 °C or 36-46 °F). (Minimum Serum: 0.5 mL)

Rejection Criteria

• Heat inactivated serum.
• Plasma specimens.
• Severely lipemic or hemolyzed specimens.

In-Lab Processing

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Room temperature is acceptable for a maximum of two hours. (Minimum Serum: 0.5 mL)

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers^® with Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 2 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers^® without Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 2 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory

Performed

Seven days a week.
Results available within 3 business days.

Reference Range

Test Methodology

Multiplex Immunoassay.

Interpretation

Elevated anti beta-2 glycoprotein I antibodies are found in the antiphospholipid antibody syndrome.

Clinical Utility

According to the most recent international consensus statement (see reference), the Antiphospholipid syndrome (APS) is present if at least one clinical criterion and one laboratory criterion are present.

Clinical criteria include:

1. Vascular thrombosis (arterial, venous, small vessel).
2. Pregnancy morbidities with fetal loss).

Laboratory criteria: These must occur on 2 or more occasions, at least 12 weeks apart and include:

1. Anticardiolipin antibodies positive with IgG greater than 40 GPL and/or IgM less than 40 MPL (NOTE: IgA anticardiolipin antibodies are not currently considered to be a laboratory criterion).
2. Anti-beta 2 glycoprotein I antibodies positive with IgG greater than 20 GPL and/or IgM greater than 10 MPL.
3. Lupus anticoagulant detected in plasma.

A diagnosis of APS is discouraged if less than 12 weeks or more than 5 years separates the positive laboratory and clinical criteria.

NOTE: Anticardiolipin antibodies may occur following acute bacterial or viral infections and in syphilis. Patients with such a history, who test positive, should be retested in 6-8 weeks to exclude transient antibodies that are usually not clinically significant.

CPT Codes

86146
LOINC:  Beta 2 Glycoprotein 1 IgM 44449-7

Contacts

Last Updated

7/21/2024