Cordarone, Pacerone, Amiodarone and Desethylamiodarone, Antrim #19017, EPIC: LAB5372, SOFT: AMIOD
Antrim #19017, EPIC: LAB5372, SOFT: AMIOD
Specimen Collection Criteria
Collect: One plain Red-top tube. (Minimum Whole Blood: 2.0 mL)
Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.
Record the exact time of specimen collection on the tube or in the computer system.
Physician Office/Draw Specimen Preparation
Let specimens clot 30-60 minutes. Centrifuge specimen to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within two hours of collection. (Minimum: 1.0 mL serum)
Preparation for Courier Transport
Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL serum)
- Serum Separator (SST) tubes.
- Severely lipemic or hemolyzed specimens.
Let specimens clot 30-60 minutes. Centrifuge specimen to separate serum from cells. Deliver immediately to the appropriate testing station.
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months
Specimen Storage in Department Prior to Disposal:
Frozen (-20°C/-4°F or below): 2 months
Royal Oak Toxicology Laboratory
Results available the same day as testing performed (1-4 days).
Therapeutic Range: 1.0-2.5 mcg/mL. (No therapeutic range exisits for Amiodarone plus Desethylamiodarone.)
Critical Level: Greater than 5.0 mcg/mL.
High Performance Liquid Chromatography with Ultraviolet Detection (HPLC/UV).
This test was developed and its performance characteristics determined by Beaumont Health. It has not been cleared or approved by the FDA. The Laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.
The half-life of a Amiodarone may be 30 days or more. Drug accumulation can result in toxicity.
The concentration of desethylamiodarone, a major metabolite, is also reported, but no therapeutic range is available. This metabolite may be pharmacologically active, but the extent of activity is not currently known with certainty.
Amiodarone (Cordarone) is an antiarrhythmic drug. This assay is used to monitor the therapeutic drug level and to evaluate potential cases of Amiodarone toxicity.
80375 (alternate: G0480).
Toxicology Laboratory – RO
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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.