Lab Test

Acyclovir Level

Zovirax , ARUP #91328, EPIC: LAB6213, SOFT: XACYB

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavender-top EDTA tube.

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.

Physician Office/Drawsite Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Min: 0.21 mL)

Rejection Criteria

  • Serum Separator (SST) Tubes.
  • Specimens not collected and processed as indicated.


Results available in 4-11 days.

Reference Range

By report.

Test Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry.


By report.

Clinical Utility

This assay aids in the therapuetic monitoring of acyclovir (Zovirax®), an antiviral drug. Zovirax® is indicated for the acute treatment of herpes zoster (shingles), the treatment of initial episodes and the managment of recurrent episodes of genital herpes and for the treatment of chickenpox (varicella).

CPT Code

80375 (alternate code: G0480).

Test Codes


Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.