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Beaumont Laboratory

Voltage Gated Calcium Channel IgG (LEMS) Autoantibodies

LEMS Autoantibody Test, Lambert-Eaton Myasthenic Syndrome (LEMS), Quest #S51602, EPIC: LAB6852, SOFT: XVGCC

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Gold-top SST tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Min: 0.2 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 48 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 35 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to Quest Diagnostics Nichols Institute, San Juan Capistrano, CA.


Results available in 5-11 days.

Reference Range

Less than 30 pmol/L.

Test Methodology

Radiobinding Assay.


Voltage-gated calcium channel (VGCC) autoantibodies are characteristic of Lambert-Eaton Myasthenic Syndrome (LEMS) with or without small-cell lung cancer. VGCC autoantibodies are also found, albeit less frequently and generally in low amounts, in paraneoplastic disease associated with lung, ovarian or breast carcinomas; in carcinomas (without LEMS or other paraneoplastic syndrome) and occasionally in neurological diseases such as amyotrophic lateral sclerosis. This assay detects p-type VGCC autoantibodies using omega-conotoxin M toxin (omega-conotoxin MVIIC).

Clinical Utility

These autoantibodies are found in Lambert-Eaton syndrome, in some patients with cancer without Lambert-Eaton syndrome and in a few patients with other neurological diseases.

CPT Code


Test Codes

Quest #S51602, EPIC: LAB6852, SOFT: XVGCC

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.