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Beaumont Laboratory

Methylphenidate & Metabolite

Ritalin, ARUP #3000253, EPIC: LAB6629, SOFT: XMPN

Specimen Collection Criteria

Collect (preferred specimen): One Gray-top Sodium Fluoride/Potassium Oxalate tube.
Also acceptable: One plain Red-top, Lavender-top EDTA, or Green-top Sodium Heparin tube.

Do not use Serum Separator Tubes.
Time of Collection: 1-6 hours post dosage.
Critical frozen. Separate samples must be submitted when multiple tests are ordered. Send specimen for processing immediately after collection.

Physician Office/Drawsite Specimen Preparation

Critical frozen. Centrifuge to separate serum or plasma from cells within 2 hours of collection. Transfer serum or plasma to a plastic transport tube and freeze (-20°C/-4°F or below) within 6 hours of collection.

Preparation for Courier Transport

Transport: 2.0 mL serum or plasma, frozen (-20°C/-4°F or below) immediatley. (Min: 1.0 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Hemolyzed specimens.
  • Specimens not collected or processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT.


Monday, Thursday.
Results available in 2-8 days.

Reference Range

Positive Cutoff:

Methylphenidate: 1 ng/mL.
Ritalinic Acid: 10 ng/mL.

Test Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry.


By report.

Clinical Utility

This assay aids in the therapuetic monitoring of Ritalin® (methylphenidate). Ritalin® is a mild central nervous system stimulant. It is indicated as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.

CPT Code

80360 (Alt. G0480).

Test Codes

ARUP #3000253, EPIC: LAB6629, SOFT: XMPN

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.