Human Herpes Virus 6 IgM

Herpesvirus 6 Antibody (IgM), HHV6, Roseola, HHV-6 IgM, HHV-6 (Human Herpesvirus-6) IgM Antibodies , FOCUS #40535, EPIC: LAB6525, SOFT: XHV6M

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Min: 0.1 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.


Tuesday - Saturday.
Results available in 2-5 days.

Reference Range


Test Methodology

Immunofluorescence Assay (IFA).


Detection of IgG and/or IgM antibodies to HHV-6 is observed only in primary, reactivated, or persistent infections which are common in the herpesvirus family. Paired testing of acute/convalescent sera is recommended, if clinically indicated.

Clinical Utility

This assay aids in the diagnosis of infection/exposure to roseola infantum and other HHV-6 infections. This assay may also be useful in the diagnosis of chronic fatigue syndrome.

Clinical Disease

HHV-6 is the causative agent of roseola infantum. Roseola is characterized by the abrupt onset of a high fever which is followed in 2-4 days by erthematous maculopapular rash that lasts for 1-2 days. Roseola lesions are macular or papular and never become vesicular like the lesions associated with VZV or HSV. Lesions typically appear on the neck and back and then spread to the abdomen and thighs The syndrome is self-limiting but convulsions associated with high fever can cause permanent neurologic injury. Atypical roseola can occur in the absence of rash (1).


  1. Wiedbrauk D, Johnston SLG. Manual of Clinical Virology, Raven Press, New York,NY, 1993.

CPT Code


Test Codes

FOCUS #40535, EPIC: LAB6525, SOFT: XHV6M

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