HLA B57 Screen for Abacavir Sensitivity
HLA-B*5701 Screening for Abacavir Hypersensitivity , EPIC: LAB6425, SOFT: CIB57
Specimen Collection Criteria
Collect: One Lavender-top EDTA tube.
Invert several times to mix well.
Physician Office/Drawsite Specimen Preparation
Do not refrigerate or freeze specimen. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport. Transport to the Laboratory within 24 hours of collection.
Preparation for Courier Transport
Transport: Whole blood at room temperature (20-26°C or 68-78.8°F).
- Unlabeled specimens.
- Specimens drawn in clot, SST, or Heparin tubes.
- This test will only be performed once in a lifetime for a patient.
Monday - Friday, 7:00 a.m. - 5:00 p.m.
Results available within 7 days.
Negative or positive for HLA-B*57:01.
Sequence Specific Priming (SSP) for HLA Class I Genotyping.
The FDA recommends that genetic testing for HLA-B*5701 be performed prior to prescribing the reverse transcriptase inhibitor, Abacavir, to HIV patients. The presence of HLA-B*5701 is associated with a drug-induced hypersensitivity reaction to Abacavir that can be prevented with prior genetic screening.
Human Immunodeficiency Virus (HIV).
- Mallal et al. HLA-B*5701 Screening for Hypersensitivity to Abacavir. The New England Journal of Medicine, 358 (6): 568-579, 2008.
EPIC: LAB6425, SOFT: CIB57