Lab Test

Interleukin 6

ARUP #51537, EPIC: LAB6292, SOFT: XINT6

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube or Dark Green-top Lithium Heparin tube.

  • Critical frozen. Send specimens for processing immediately after collection.
  • Separate samples must be submitted when multiple tests are ordered.

Note: Patient Preparation: Twenty-four (24) hours before this test, the patient should not take multivitamins or dietary supplements containing biotin (vitamin B7) which is commonly found in hair, skin and nail supplements and multivitamins.

Physician Office/Drawsite Specimen Preparation

Critical frozen. Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, frozen (-20°C/-4°F or below). (Min: 0.3 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated. 


Monday, Wednesday, Friday.
Results available in 2-5 days.

Reference Range

Less than 5 pg/mL.

Test Methodology

Quantitative Multiplex Bead Assay.

Clinical Utility

IL-6, a multi-functional cytokine produced by a range of cells, plays a central role in host defense mechanisms, is involved in induction of B-cell differentiation, induction of IL-2 and IL-2 receptor expression and proliferation and differentiation of T cells. Elevated IL-6 concentrations are reported in a variety of autoimmune diseases (e.g., rheumatoid arthritis), proliferative diseases (e.g., mesangial proliferative glomerulonephritis), and malignancies (e.g., leukemia and lymphoma).

CPT Code


Test Codes

ARUP #51537, EPIC: LAB6292, SOFT: XINT6

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.