Disopyramide Level
Norpace®, Napamide®, Rythmodan
Test Codes
ARUP #2011632, Order as a Miscellaneous Send Out.
Specimen Collection Criteria
Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavender-top EDTA tube.
Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.
Physician Office/Draw Specimen Preparation
Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).
Preparation for Courier Transport
Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)
Rejection Criteria
Serum Separator (SST) tubes.
Specimens not collected and processed as indicated.
In-Lab Processing
Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).
Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)
Storage
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 4 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 2 months
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.
Laboratory
Sent to ARUP Laboratories, Salt Lake City, UT.
Performed
Tuesday, Friday.
Results available in 2-6 days.
Reference Range
Therapeutic: 2.0-6.0 mcg/mL.
Toxic: Greater than 6.0 mcg/mL.
Test Methodology
Quantitative Enzyme Multiplied Immunoassay Technique.
Interpretation
Disopyramide exhibits nonlinear protein binding within the therapeutic range. Unbound Disopyramide increases disproportionatly to increases in Disopyramide dosing.
Clinical Utility
Disopyramide is used in the treatment of unifocal premature (ectopic) ventricular contractions and ventricular tachycardia. This assay is used for the therapeutic monitoring and toxicity assessment of disopyramide.
CPT Codes
80299
Contacts
Send Outs Laboratory – RO
248-551-9045
Name: Send Outs Laboratory – RO
Location:
Phone: 248-551-9045
Last Updated
5/27/2021
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