Lamictal, Antrim #81245, EPIC: LAB5397, SOFT: LAMOT
Specimen Collection Criteria
Collect: One plain Red-top tube. (Minimum Whole Blood: 2.0 mL)
Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.
Record the exact time of specimen collection on the tube or in the computer system.
Physician Office/Drawsite Specimen Preparation
Let specimens clot 30-60 minutes. Refrigerate (2-8°C or 36-46°F) the collection tube within two hours of collection. (Min: 2.0 mL blood)
Preparation for Courier Transport
Transport: Collection tube, refrigerated (2-8°C or 36-46°F). (Min: 2.0 mL blood)
- Serum Separator (SST) tubes.
- Severely lipemic or hemolyzed specimens.
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 8 hours
Frozen (-20°C/-4°F or below): 3 months
Specimen Storage in Department Prior to Disposal:
Frozen (-20°C/-4°F or below): 2 months
Royal Oak Toxicology Laboratory.
Sunday - Saturday.
Routine results available the same day as testing performed (1-2 days).
Therapeutic Range: 3-12 mcg/mL.
Critical Value: 25 mcg/mL.
Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS).
This test was developed and its performance characteristics determined by Beaumont Health. It has not been cleared or approved by the FDA. The Laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.
Initial indications for a therapeutic range of 1-4 mcg/mL for Lamotrigine appear to be conservative and the literature supports a broader range of acceptable values. See Morris et al., Br J Clin Pharmacol 46:547-551, 1998.
Lamotrigine is an antiepileptic drug that is effective as adjunctive therapy in treating resistant partial and generalized tonic clonic seizures. It also aids in the treatment of some patients with Lennox-Gastaut syndrome and in children with multiple seizure types. This assay is used for the therapeutic monitoring and toxicity assessment of lamotrigine.
Antrim #81245, EPIC: LAB5397, SOFT: LAMOT
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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills,
Grosse Pointe, Royal Oak, and Troy campuses.