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Beaumont Laboratory

Lamotrigine Level

Lamictal, Antrim #81245, EPIC: LAB5397, SOFT: LAMOT

Specimen Collection Criteria

Collect: One plain Red-top tube. (Minimum Whole Blood: 2.0 mL)

Do not use Serum Separator Tubes.
Time of Collection:
 Trough, just prior to the next dose.
Record the exact time of specimen collection on the tube or in the computer system.

Physician Office/Drawsite Specimen Preparation

Let specimens clot 30-60 minutes.  Refrigerate (2-8°C or 36-46°F) the collection tube within two hours of collection. (Min: 2.0 mL blood)

Preparation for Courier Transport

Transport: Collection tube, refrigerated (2-8°C or 36-46°F). (Min: 2.0 mL blood)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Severely lipemic or hemolyzed specimens. 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 8 hours
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Frozen (-20°C/-4°F or below): 2 months

Laboratory

Royal Oak Toxicology Laboratory.

Performed

Sunday - Saturday.
Routine results available the same day as testing performed (1-2 days).

Reference Range

Therapeutic Range: 3-12 mcg/mL.
Critical Value: 25 mcg/mL.

Test Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS).

This test was developed and its performance characteristics determined by Beaumont Health. It has not been cleared or approved by the FDA. The Laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.

Interpretation

Initial indications for a therapeutic range of 1-4 mcg/mL for Lamotrigine appear to be conservative and the literature supports a broader range of acceptable values. See Morris et al., Br J Clin Pharmacol 46:547-551, 1998.

Clinical Utility

Lamotrigine is an antiepileptic drug that is effective as adjunctive therapy in treating resistant partial and generalized tonic clonic seizures. It also aids in the treatment of some patients with Lennox-Gastaut syndrome and in children with multiple seizure types. This assay is used for the therapeutic monitoring and toxicity assessment of lamotrigine.

CPT Code

80175.

Test Codes

Antrim #81245, EPIC: LAB5397, SOFT: LAMOT

Last Updated

09/19/2016

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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.