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Beaumont Laboratory

Vanillylmandelic Acid (VMA), Urine 24 hour

VMA, Urine Vanillylmandelic Acid, Vanillymandelic Acid (VMA), Urine 24 hr, Vanillylmandelic Acid, Urine (VMA), WARDE: UVMA, EPIC: LAB7066, SOFT: XVM24

Instructions

If a random sample for Vanillylmandelic Acid is requested, please see Vanillylmandelic Acid (VMA), Urine Random.

Specimen Collection Criteria

Collect: 24 hour urine sample with 15 mL of 6N Hydrochloric Acid added prior to the start of collection.

  • Keep 24 hour urine specimen iced or refrigerated during collection.
  • Include start and end dates and times for the collection period on the specimen container.
Urine Preservative Options
No Preservative
6N Hydrochloric Acid
Boric Acid (10g)
Sodium Carbonate
50% Acetic Acid
Acceptable
PREFERRED
Unacceptable
Unacceptable
Unacceptable

Physician Office/Drawsite Specimen Preparation

Maintain specimens refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: Entire 24 hour urine collection, refrigerated (2-8°C or 36-46°F).

Rejection Criteria

  • Samples not kept refrigerated (2-8°C or 36-46°F).
  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing (preserved):

Room Temperature (20-26°C or 68-78.8°F): 10 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Stability for Testing (unpreserved):

Room Temperature (20-26°C or 68-78.8°F): unacceptable
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to Warde Medical Laboratory, Ann Arbor, MI.

Performed

Monday, Wednesday, Friday.
Results are available in 4-7 days.

Reference Range

By report.

Test Methodology

High-Performance Liquid Chromatography (HPLC).

Interpretation

Elevated levels are seen in cases of pheochromocytoma, neuroblastoma, ganglioneuroma and in some cases of carcinoid tumor.

Clinical Utility

Vanillylmandelic Acid is the primary metabolite of the catecholamines. Quantitation of VMA has been valuable in the diagnosis and follow-up of patients with phenochromocytoma and related neurogenic tumors. Catecholamine-secreting tumors are surgically curable; therefore, it may be desirable to evaluate hypertensive patients for this possible cause.

CPT Code

84585, 82570.

Test Codes

WARDE: UVMA, EPIC: LAB7066, SOFT: XVM24

Last Updated

01/25/2018

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.