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Beaumont Laboratory

Hepatitis A Antibody Total (HAV T)

HAV Ab, Hepatitis A Antibodies, Total (HAVAb), Hepatitis A Antibody Total (HAV T), Antrim #31331, EPIC: LAB5218, SOFT: HAVT

Instructions

Hepatitis A Antibody (Total) measures both IgG and IgM antibodies but does not differentiate between them.

Note: Patient Preparation (Royal Oak ONLY): Twenty-four (24) hours before this test, the patient should not take multivitamins or dietary supplements containing biotin (vitamin B7) which is commonly found in hair, skin and nail supplements and multivitamins.

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube. (Minimum Whole Blood: 4.0 mL)
Also acceptable: One Lavender-top EDTA tube. (Minimum Whole Blood: 3.0 mL)

Contact the Laboratory for the acceptability of other tube types. 

Physician Office/Drawsite Specimen Preparation

Let SST specimens clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged SST tube within two hours of collection.

Centrifuge Lavender-top tube immediately to separate plasma from cells. Transfer 3.0 mL plasma to plastic transport tube and refrigerate (2-8°C or 36-46°F) within two hours of collection. 

Preparation for Courier Transport

Transport: Centrifuged SST tube or 2.0 mL plasma, refrigerated (2-8°C or 36-46°F). (Min: 2.0 mL serum or plasma)

Rejection Criteria

  • Severely lipemic or hemolyzed specimens.
  • Red-top tubes with serum not separated from cells within two hours of collection.

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers® with Separator Gel
Room Temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers® without Separator Gel
Room Temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 7 days

Plasma Specimens (Aliquots)
Room Temperature (20-26°C or 68-78.8°F): 12 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 7 days

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Automated Chemistry Laboratory.

Performed

Sunday - Saturday, 24 hours a day.
Results available within 24 hours of receipt in the Laboratory.

Reference Range

Negative.

Test Methodology

Chemiluminescence Immunoassay.

Interpretation

This assay tests for IgG and IgM antibodies but does not differentiate between them. For diagnostic purposes, the anti-HAV reactivity should be correlated with patient history and other hepatitis markers for diagnosis of past or present infection.

Clinical Utility

The presence of anti-HAV in human serum or plasma is indicative of past or present infection with Hepatitis A virus. The test for total Anti-HAV is primarily used to determine previous exposure to hepatitis A virus. The result of this assay may be used to assess immune status or for epidemiological studies.

Clinical Disease

The symptoms of hepatitis A may include fatigue, poor appetite, fever and vomiting. Urine may become darker in color, and then jaundice may appear. The disease is rarely fatal and most people recover in a few weeks without any complications. Infants and young children tend to have very mild symptoms and are less likely to develop jaundice than older children and adults. The incubation period is 10-50 days with a mean incubation time of 1 month. (1)

Epidemiology

Hepatitis A has a worldwide distribution and man is the only known reservoir for the virus. Recurrent epidemics are a prominent feature of the disease. In the U.S., the disease appears to peak in the fall and winter months. HAV is endemic in many developing countries and childhood infection is common. In developing countries, up to 90% of adults have antibodies to the virus. In industrialized countries HAV antibodies are uncommon in young children (<5%) but they are present 5-20% of those under 20 years of age and in 30-50% of older adults. (1)

Transmission

Transmission is predominantly by the fecal-oral route or through contaminated water or food. Fomites and person-to-person spread are principal means of transmission, especially in day care centers handling children under two years of age. Patients are infectious 2-3 weeks before the onset of symptoms and for approximately 8 days thereafter. (1)

Reference

  1. Wiedbrauk D, Johnston SLG. Manual of Clinical Virology, Raven Press, New York, NY, 1993.

CPT Code

86708.

Test Codes

Antrim #31331, EPIC: LAB5218, SOFT: HAVT

Last Updated

12/29/2017

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.